Human genetics of the metabolic syndrome
Journal
Asia Pacific Journal of Clinical Nutrition
Journal Volume
17
Journal Issue
SUPPL. 1
Pages
43-46
Date Issued
2008
Author(s)
Abstract
Genetic studies of metabolic syndrome provide a means to identify key pathways that predispose individuals to various phenotypes of the metabolic diseases and risk factors to type 2 diabetes and cardiovascular disease. Both genome wide linkage and association studies have been attempted to answer this issue. In this minireview, I will address genetic studies in Chinese in both family and population samples. The works of genome scan of were reported from the SAPPHIRe cohort as an example to address the linkage approaches to unraveling genetics of various traits composing the metabolic syndrome. In addition, some of the important biological candidate genes were also discussed. Finally, the success of finding genes through genome wide association for the metabolic syndrome remains to be explored.
Subjects
Candidate genes; Genetic factors; Linkage mapping; Metabolic syndrome
SDGs
Other Subjects
chromosome map; ethnic group; genetic predisposition; genetics; human; metabolic syndrome X; review; risk factor; Chromosome Mapping; Ethnic Groups; Genetic Predisposition to Disease; Humans; Metabolic Syndrome X; Risk Factors
Type
review