Monascus purpureus-fermented products and oral cancer: A review
Journal
Applied Microbiology and Biotechnology
Journal Volume
93
Journal Issue
5
Pages
1831-1842
Date Issued
2012
Author(s)
Abstract
Tobacco and alcohol consumption have been reported as major factors for the development of oral cancer. Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products have many functional secondary metabolites, including monacolin K, citrinin, ankaflavin, and monascin. In several recent studies performed in our laboratory, these secondary metabolites have shown anti-inflammatory, anti-oxidative, and anti-tumor activities. Many published studies have shown the efficacy of Monascus-fermented products in the prevention of numerous types of cancer. The current article discusses and provides evidence to support that Monascus-fermented metabolites may be developed as painting drugs for the mouth to prevent or cure oral carcinogenesis. This is a novel therapeutic approach focusing on tumor growth attenuation to improve patient survival and quality of life. ? 2012 Springer-Verlag.
Subjects
Metabolite; Monascus purpureus; Oral cancer; Red mold dioscorea; Red mold rice
SDGs
Other Subjects
Alcohol consumption; Anti-inflammatories; Anti-tumor activities; Citrinin; Major factors; Monascus; Monascus purpureus; Oral cancer; Oral carcinogenesis; Quality of life; Red mold dioscorea; Red mold rice; Secondary metabolites; Traditional Chinese Medicine; Tumor growth; Metabolism; Metabolites; Molds; Diseases; 4 aminobutyric acid; ankaflavin; biological product; celecoxib; cholestin; dimerumic acid; mevinolin; monascin; monascorubrin; red mold dioscorea; rubropunctatin; unclassified drug; xanthomonascin A; yellow II; biotechnology; cancer; disease treatment; drug development; edible species; fermentation; laboratory method; literature review; metabolite; oral health; quality of life; rice; survival; traditional medicine; tumor; antineoplastic activity; cancer survival; carcinogenesis; drug structure; fermented product; human; Monascus purpureus; mouth cancer; nonhuman; oral squamous cell carcinoma; quality of life; short survey; tumor growth; Antineoplastic Agents; Asia; Fermentation; Humans; Monascus; Mouth Neoplasms; Far East; Dioscorea; Fungi; Monascus; Monascus purpureus; Nicotiana tabacum
Type
journal article