Real-World Experience with Idarucizumab to Reverse Anticoagulant Effect in Dabigatran-Treated Patients: Report of 11 Cases from Taiwan
Journal
Journal of Stroke and Cerebrovascular Diseases
Journal Volume
27
Journal Issue
2
Pages
e27-e33
Date Issued
2018
Author(s)
Lin H.-J.
Chua S.-K.
Liao P.-C.
Yang Y.-P.
Chou P.-C.
Lee C.-W.
Lin M.-J.
Chen H.-M.
Yeh J.-T.
Li Y.-H.
Abstract
Background: This study aims to observe the effectiveness and safety of idarucizumab in dabigatran-treated patients with severe bleeding or requiring surgery in Taiwan. Methods and Results: In Taiwan, 11 dabigatran-treated patients developed severe bleeding, fracture that needed surgery, and acute ischemic stroke requiring thrombolysis. These patients were treated with idarucizumab and obtained adequate hemostasis. Our experiences reconfirmed the efficacy and safety of idarucizumab in Asian patients. Conclusions: Idarucizumab improves safety in dabigatran-treated patients. Continued education about the availability and appropriate use of idarucizumab is necessary in Asia. ? 2018 National Stroke Association
Subjects
anticoagulation reversal; bleeding; dabigatran; Idarucizumab; surgery; thrombolysis
SDGs
Other Subjects
alteplase; clopidogrel; dabigatran; idarucizumab; rivaroxaban; warfarin; antithrombin; dabigatran; idarucizumab; monoclonal antibody; activated partial thromboplastin time; aged; anticoagulation; Article; atrial fibrillation; bleeding; blood clot lysis; brain hematoma; brain ischemia; clinical article; computer assisted tomography; creatinine clearance; dizziness; drowsiness; drug effect; drug efficacy; drug safety; female; fiberscope endoscopy; fracture; hemianopia; hemiparesis; hemoglobin blood level; hemostasis; human; male; nuclear magnetic resonance imaging; priority journal; rectum hemorrhage; subarachnoid hemorrhage; subdural hematoma; Taiwan; treatment response; very elderly; antagonists and inhibitors; bleeding; blood clotting; case report; chemically induced; evidence based medicine; operative blood loss; risk factor; severity of illness index; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antithrombins; Blood Coagulation; Blood Loss, Surgical; Dabigatran; Evidence-Based Medicine; Female; Hemorrhage; Humans; Male; Risk Factors; Severity of Illness Index; Taiwan
Type
journal article