Exploring the Association between Dietary Habits and arkinson’s Disease A Community - Based Neurology Survey
Date Issued
2008
Date
2008
Author(s)
Wen, Chiung-Jung
Abstract
Background and Study Purpose Parkinson’s disease (PD) is the second most common degenerative disorder in the aging brain after Alzheimer’s dementia with geographical variation, which suggests the possibility of interaction between genetic susceptibility and environmental risk factors related to endo- and exotoxins. One of major considerations is nutrition. From epidemiological viewpoint, there is lacking of large population-based study to report incidence and prevalence rate simultaneously and also to demonstrate the associations between various dietary habits and the risk of PD. Thus, the aim of the present study is firstly to estimate the incidence and prevalence of PD in the community in Taiwan, and secondly, to elucidate the effect of a series of life-style, dietary habits, and their related biological markers on the risk of PD using a population-based cohort study.aterial and Methods Study subjects enrolled in our study for the following analysis are originated form the participants involved in Keelung community-based integrated screening program (KCIS) from 2000 to 2005. A one-stage neurological survey for idiopathic PD was also conducted in 2001. As our study subjects are from community-based residents, we have two ways of detecting PD, active and passive method. In active method, we used one-stage method in a cross-sectional survey to detect PD by the Neurologists in 2001. In passive method, we exploited data on the enrollment of screenee between 2001 and 2005 to estimate prevalence rate in each year by the linkage of these screenee with health insurance claimed record to find 701 PD cases. Information on anthropometric measurement, blood pressure measurement, biochemical markers, personal medical history, food intake questionnaire, and life style factors were collected. Logistic regression model with adjustment for potential confounders was used to estimate the association between different dietary factors and PD risks.esult Among 11,330 participants who received screening for PD by the neurologists in 2001, 80 PD cases were detected. Of remain 11,250 participants who were free from PD in 2001, 157 participants were diagnosed as PD in the following 4 years. The incidence rate was around 232.3~366.0 per 105 person-years. The prevalence rate was 706 per 105population when using active method to detect PD cases. The prevalence rate was about two-fold when comparing with the passive detection method. In early PD analysis, which PD cases was detected by active method, we found that age was a risk factor for PD (RR:1.11 , 95% CI: 1.01-1.14). Female gender is a protective factor for PD though it was not statistically significant (RR: 0.74, 95% CI: 0.47-1.16). Seafood intake was inversely associated with PD (p for trend: 0.04). In late PD analysis, which PD cases was detected by passive method, the risk for PD also increased with age (RR:1.09 , 95% CI: 1.08-1.10). For dietary habits, an increase in intake of fruit was positively associated with the risk of PD (p for trend: 0.02). Intake of caffeine (p for trend: 0.004) and high total calorie intake per day (p for trend: 0.001) were inversely associated with the risk for PD. Those who had cardiovascular disease history (RR:1.38, 95% CI:1.12-1.68) and osteoporosis(RR:1.63, 95% CI:1.37-1.94) were more prone to having late PD than those who were in the absence of corresponding diseases or disease history. Smoking (RR:0.76 , 95% CI: 0.61-0.96), alcohol drinking(RR:0.76 , 95% CI: 0.59-1.00) and chronic disease with hyperlipidemia (RR:0.78 , 95% CI: 0.67-0.92) were inversely associated with the risk of PD.onclusion Our study used two ways of detecting PD, active and passive method. The prevalence rate using active method of detecting PD was about two-fold higher than passive method. By using a neurological survey we found an inverse relationship of seafood to early PD among Chinese people. Regarding progression to symptomatic PD we also found coffee, high calorie intake per day, smoking, alcohol drinking and hyperlipidemia were negatively associated with the risk of PD. The presence of osteoporosis and cardiovascular disease history are positively related to the risk of PD. The influence of some risk factors is rather elusive and need further study to conform these relationships.
Subjects
Parkinson’s disease
dietary habits
prevalence
community-based screening
active detection
passive detection
SDGs
Type
thesis
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