Analyzing Biomarker in Breast Ultrasound
Date Issued
2015
Date
2015
Author(s)
Huang, Yao-Sian
Abstract
Breast cancer has become the most fatal disease among women. Beside the treatment of breast cancer, the relapse and survival rate are also the important information. With the advance of medical technology, the biomarkers of breast cancer have been defined and investigated. Different subtypes of biomarkers response to the different treatment therapy, relapse, and survival rate, especially the triple-negative tumors that have the worst prognosis and highest relapse rate. Hence, it is helpful to determine the treatment planning and evaluate the prognosis if the biomarker information is obtained as early as possible. Ultrasound (US) is a cheaper, non-invasive, effective against to eliminate the influence of dense tissue, and has been widely used in breast examination. With the growth of US technique, the angiogenesis around tumor has been displayed on the US imaging with the Doppler effect and provided additional information for diagnosis. Therefore, for constructing the efficient diagnosing processes, various computer-aided diagnosis (CAD) systems have been developed based on US to quantify the imaging characteristics for supplying a convenient and immediate assistance. In this study, the morphology and texture features of angiogenesis and tumor are quantified by using the proposed CAD systems and then the correlations among distant subtypes of biomarkers are analyzed and evaluated.
Subjects
Breast cancer
ultrasound
computer-aided diagnosis
Doppler effect
triple-negative breast cancer
SDGs
Type
thesis
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