鼻咽癌與DNA修補基因之流行病學研究(III)
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
鄭玉娟
DOI
922320B002168
Abstract
Genetic polymorphisms of DNA
repair genes have been reported to
determine susceptibility to several
cancers. This study focused on effects of
genetic polymorphisms of DNA repair
genes hMLH1 and LIG1 interacted with
environmental factor on the
development of nasopharyngeal
carcinoma (NPC).
The incidence of nasopharyngeal
carcinoma in Chinese is the highest in
the world. It is 20-30 times compared to
Caucasian, and also much more than Japanese and Korean. Compared to other
cancers, the peak of nasopharyngeal
carcinoma more frequently occurs in
younger age and dominant in male. The
impact of the disease especially can not
be ignored. The specific aim of this
study is to explore the risk factors of
nasopharyngeal carcinoma (NPC). A
case-control study for NPC which was
collaborated with College of Medicine,
College of Public Health National
Taiwan University and the National
Institute of Health in America was
conducted in Taiwan from July 1991 to
December 1994 to investigate the
interaction of environmental carcinogen
and genotype polymorphism to the risk
of NPC. We enrolled 335 histologically
confirmed incident NPC cases who were
younger than 75 years old, and had
resided in Taipei city/county for at least
6 months, from National Taiwan
University Hospital and Mackay
Memorial Hospital. Totally 281 healthy
community controls were selected by
individual matching for sex, age and
residence. The study will use the
real-time polymerase chain reaction
(RTPCR) to analyze the geno types of
DNA repair genes hMLH1 and LIG1.
Information of Risk factors were
obtained through personal interview
with structured questionnaire, in which
included demographic factors, the
history of smoking, drinking, dietary
habit, family history of cancer etc. The
information were combined with
genotyping results to evaluate the effect
of NPC development. Unconditional
logistic regression was performed to
clarify the relationship between various
risk factors, genetic susceptibility and
NPC occurrence, and also to elucidate
their interaction. After adjusting age, sex,
ethnicity, educational level, and duration
of smoking, NPC is significantly
associated with genetic polymorphisms
of hMLH1 ，while LIG1 is not. We
further stratified by anti-EBV antibodies,
occupational exposure to wood dust and
formaldehyde, and dietary nitrosamine
intake. When stratified 0-10 years
exposure to either formaldehyde or
wood dust, NPC risk is significantly
correlated with hMLH1 polymorphism,
while remained no significant
association between NPC risk and LIG1.
Subjects
nasopharyngeal
carcinoma
carcinoma
case-control study
risk
factor
factor
DNA repair
genes
genes
genetic
polymorphism
polymorphism
susceptibility
SDGs
Publisher
臺北市：國立臺灣大學公共衛生學院流行病學研究所
Type
report
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