Synthesis and Activity of Derivatives of Anti-Influenza Drug Zanamivir (Relenza®)
Date Issued
2007
Date
2007
Author(s)
Chang, Wen-Yen
DOI
zh-TW
Abstract
Abstract
Influenza virus is still a major worldwide health problem today that causes substantial morbidity and mortality. Recently, the H5N1 subtype of avian influenza virus has spread over China, Africa, and European union mainly by migratory birds. Wild waterfowls are the major reservoir of influenza viruses, and all influenza viruses in other animal species are thought to be derived from these birds.
The zanamivir is one of the most potent inhibitors of influenza neuraminidase (NA), which is believed to catalyze the cleavage of terminal sialic acid residues. The zanamivir at C7 position does not influence the recognition with influenza virus, thus it can be modified to combine with nanoparticle to enhance the binding affinity presumably via multivalent effect. The zanamivir linked magnetic nanoparticle has the advantageous features of multivalency effect, easy isolation of influenza virus for assay, and well control to reach the target cell of infection.
On the other hand, the zanamivir at C7 position can be modified to couple caffeic acid. Caffeic acid, a phenolic acid present in many dietary plants has been shown to confer antioxidant and anti-inflammatory activities. So it may make the drug more functional against influenza virus.
Subjects
禽流感
唾液酸
咖啡酸
流感病毒
avian influenza
sialic acid
caffeic acid
influenza virus
Type
thesis
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