CMV Retinitis with Panretinal Occlusive Vasculitis.
Journal
Ocular immunology and inflammation
Journal Volume
32
Journal Issue
5
Start Page
477
End Page
484
ISSN
1744-5078
Date Issued
2024-07
Author(s)
Abstract
Purpose: To report the clinical features of cytomegalovirus (CMV) retinitis with panretinal occlusive vasculitis.
Methods: Retrospective case series.
Results: Four eyes in 3 non-HIV patients (male: female = 3:0) were included. Previous medical history included diabetes mellitus (n = 2), age-related macular degeneration (n = 1), and Multiple myeloma under chemotherapy (n = 1). All patients were treated with oral valganciclovir and intravitreal ganciclovir. Slow resolution of retinitis related retinal opacification was noted in all 4 eyes. Two eyes had anti-viral agents discontinued despite the persistent retinitis related opacification and the lesions slowly resolved in the following months. The final decimal visual acuity was equal to or worse than 0.02 in 3 of the 4 eyes.
Conclusion: In eyes of CMV retinitis with panretinal occlusive vasculitis, rapid resolution of retinitis lesions is an unreliable sign evaluating the therapeutic efficacy of anti-viral agents. Besides, despite treatment of anti-viral agents, deteriorating vascular occlusion may further endanger macular function.
Subjects
CMV retinitis
Chronic CMV retinitis
cytomegalovirus retinitis
immunocompromised patients
panretinal occlusive vasculitis
Type
journal article