Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study
Journal
PLoS ONE
Journal Volume
9
Journal Issue
7
Pages
e98158
Date Issued
2014
Author(s)
Abstract
Background: Previous studies on the association between tuberculosis and the risk of developing ischemic stroke have generated inconsistent results. We therefore performed a population-based, propensity score-matched longitudinal follow-up study to investigate whether contracting non-central nervous system (CNS) tuberculosis leads to an increased risk of ischemic stroke. Methods: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 5804 persons with at least three ambulatory visits in 2001 with the principal diagnosis of non-CNS tuberculosis were enrolled in the tuberculosis group. The non-tuberculosis group consisted of 5804, propensity score-matched subjects without tuberculosis. The three-year ischemic stroke-free survival rates for these 2 groups were estimated using the Kaplan-Meier method. The stratified Cox proportional hazards regression was used to estimate the effect of tuberculosis on the occurrence of ischemic stroke. Results: During three-year follow-up, 176 subjects in the tuberculosis group (3.0%) and 207 in the non-tuberculosis group (3.6%) had ischemic stroke. The hazard ratio for developing ischemic stroke in the tuberculosis group was 0.92 compared to the non-tuberculosis group (95% confidence interval: 0.73-1.14, P = 0.4299). Conclusions: Non-CNS tuberculosis does not increase the risk of subsequent ischemic stroke. ? 2014 Wu et al.
SDGs
Other Subjects
adult; age; ambulatory care; article; brain ischemia; controlled study; female; follow up; gender; human; major clinical study; male; propensity score; risk factor; social status; survival rate; tuberculosis; aged; brain ischemia; complication; factual database; incidence; middle aged; propensity score; risk; Stroke; Taiwan; tuberculosis; Adult; Aged; Brain Ischemia; Databases, Factual; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Propensity Score; Risk; Stroke; Survival Rate; Taiwan; Tuberculosis
Publisher
Public Library of Science
Type
journal article