Human immunodeficiency virus-associated nephropathy
Journal
Journal of the Formosan Medical Association
Journal Volume
105
Journal Issue
8
Pages
680-684
Date Issued
2006
Abstract
Human immunodeficiency virus-associated nephropathy (HIVAN) is characterized by high-grade proteinuria and rapid progression to end-stage renal disease (ESRD). Despite the large numbers of HIV-infected cases in Asian countries, data on HIVAN in this area are limited. We report a 54-year-old Taiwanese man with HIVAN who presented with cytomegalovirus retinitis, renal insufficiency (serum creatinine, 3.8 mg/dL) and nephrotic range proteinuria with a daily protein loss of 10.8g. Despite highly active antiretroviral therapy (HAART) for 31 months, renal failure developed requiring maintenance hemodialysis. Renal biopsy showed collapsing focal segmental glomerular sclerosis, podocyte proliferation and tubulointerstitial nephritis with mononuclear cell infiltration. These features were compatible with HIVAN. Although hemodialysis was instituted, he died 2 months later due to nosocomial pneumonia complicated with multiple organ failure. In summary, this case of HIVAN in a Taiwanese patient shows that the condition may progress to ESRD despite successful viral suppression with HAART. ? 2006 Elsevier & Formosan Medical Association.
SDGs
Other Subjects
amlodipine; antiretrovirus agent; atorvastatin; creatinine; efavirenz; lamivudine; stavudine; adult; article; case report; cell infiltration; cell proliferation; clinical feature; creatinine blood level; death; disease association; disease duration; dyslipidemia; dyspnea; focal glomerulosclerosis; hemodialysis; highly active antiretroviral therapy; hospital admission; human; Human immunodeficiency virus infection; hydronephrosis; hyperkalemia; hypertension; interstitial nephritis; kidney biopsy; kidney disease; kidney failure; kidney tubule; male; metabolic acidosis; mononuclear cell; multiple organ failure; pneumonia; podocyte; protein depletion; proteinuria; retinitis; septic shock; Taiwan; ureter stent; ureter stone; ureterolithotomy
Publisher
Scientific Communications International Ltd
Type
journal article