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The Roles of Neurotrophins in Traumatic Brain Injury
Journal
Life (Basel, Switzerland)
Journal Volume
12
Journal Issue
1
Date Issued
2021-12-24
Author(s)
Abstract
Neurotrophins are a collection of structurally and functionally related proteins. They play important roles in many aspects of neural development, survival, and plasticity. Traumatic brain injury (TBI) leads to different levels of central nervous tissue destruction and cellular repair through various compensatory mechanisms promoted by the injured brain. Many studies have shown that neurotrophins are key modulators of neuroinflammation, apoptosis, blood-brain barrier permeability, memory capacity, and neurite regeneration. The expression of neurotrophins following TBI is affected by the severity of injury, genetic polymorphism, and different post-traumatic time points. Emerging research is focused on the potential therapeutic applications of neurotrophins in managing TBI. We conducted a comprehensive review by organizing the studies that demonstrate the role of neurotrophins in the management of TBI.
Subjects
NT-3; NT-4/5; brain-derived neurotrophic factor; nerve growth factor; neurotrophins; traumatic brain injury
Publisher
MDPI
Type
journal article