Comparison of DNA Methylation Changes Between the Gestation Period and the After-Delivery State: A Pilot Study of 10 Women
Journal
Frontiers in nutrition
Journal Volume
9
Date Issued
2022
Author(s)
Abstract
Gestational adaptation occurs soon after fertilization and continues throughout pregnancy, whereas women return to a pre-pregnancy state after delivery and lactation. However, little is known about the role of DNA methylation in fine-tuning maternal physiology. Understanding the changes in DNA methylation during pregnancy is the first step in clarifying the association of diet, nutrition, and thromboembolism with the changes in DNA methylation. In this study, we investigated whether and how the DNA methylation pattern changes in the three trimesters and after delivery in ten uncomplicated pregnancies.
Subjects
DNA methylation; after-pregnancy status; gestational adaptation; pathway analysis; pregnancy
Publisher
FRONTIERS MEDIA SA
Type
journal article