Risk factors for acute toxoplasma gondiidiseases in Taiwan: A population-based case-control study
Journal
PLoS ONE
Journal Volume
9
Journal Issue
3
Date Issued
2014
Author(s)
Abstract
Although human toxoplasmosis is a notifiable disease in Taiwan since 2007, little is known about its risk factors. This study aimed to investigate the risk factors for acute Toxoplasma gondii diseases in Taiwan. We conducted a nationwide population-based case-control study. Cases of acute human toxoplasmosis notified to the Taiwan Centers for Diseases Control (Taipei, Taiwan) during 2008-2013 were compared with controls that were randomly selected from healthy T. gondii-seronegative blood donors who participated in a nationwide T. gondii seroepidemiologic study during 2009-2010. Cases and controls were matched according to age, gender and residency at an 1:8 ratio. Structured questionnaires were used to gather information regarding risk factors. A total of 30 laboratory-confirmed acute T. gondii disease cases and 224 controls were enrolled. The most common clinical manifestation of the cases was flu-like symptoms (n = 20), followed by central nervous system disease (n = 4), ocular diseases (n = 3), abortion (n = 2), and congenital infection (n = 1). Multivariate conditional logistic regression showed that raw clam consumption (adjusted odds ratio [OR] = 3.7; 95% confidence interval [CI] = 1.4-9.9) and having a cat in the household (adjusted OR = 2.9; 95% CI = 1.1-7.9) were two independent risk factors for acute T. gondii disease. We conclude that raw shellfish consumption and domestic cat exposure were risk factors for acquiring acute T. gondii diseases in Taiwan. This finding may guide future research and control policies. ? 2014 Chiang et al.
SDGs
Other Subjects
abortion; adolescent; adult; age; article; case control study; cat; central nervous system disease; clam; clinical article; clinical feature; congenital infection; controlled study; domestic animal; eye disease; female; flu like syndrome; food intake; gender; human; infection risk; male; risk factor; sea food; seroepidemiology; Taiwan; toxoplasmosis; animal; bivalve; cat disease; disease carrier; middle aged; parasitology; pathogenicity; physiology; questionnaire; risk factor; Toxoplasma; toxoplasmosis; transmission; Adolescent; Adult; Animals; Bivalvia; Case-Control Studies; Cat Diseases; Cats; Disease Reservoirs; Female; Humans; Male; Middle Aged; Questionnaires; Risk Factors; Taiwan; Toxoplasma; Toxoplasmosis
Publisher
Public Library of Science
Type
journal article