Total Synthesis of Thermophilic Bacteria Phosphoglycolipid and its Influence in Antagonist of Lipopolysaccharide
Date Issued
2009
Date
2009
Author(s)
Wang, Hsing-Hsiang
Abstract
The structure of phosphoglycolipid have been well studied, but the real biological function of these compound are not cleared identified. According to our previous report, PGL1/PGL2 mixture from M. taiwanensis and T. oshimai, but not T. thermophilus and M. ruber, up-regulate interleukin-1b (IL-1b) production in human THP-1 monocytes and blood-isolated primary monocytes. In addition, PGL2 did not induce proIL-1 production but inhibited PGL1-mediated proIL-1 production, showing that PGL1 is the main inducer of proIL-1 production in PGL1/PGL2 mixture.ur lab found that PGL1 could decrease LPS activity (unpublished), in other words, PGL1 may have the possibility to become the candidate of LPS antagonist or else. For these reason, our target is to acquire the pure PGL1 by organic synthesis, to straighten out these questions, including the influence of the acyl chain of PGL1, receptor of PGL1, and the exdotoxin tolerance activity. This study is focused on the total synthesis of PGL1 in different length of alkyl chain, and the LPS tolerance activity in human THP-1 cell.
Subjects
thermophilic bacteria
phosphoglycolipid
interleukin-1
lipopolysaccharide
endotixin tolerance
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