Fano enhancement of SERS for rapid early diagnosis of colorectal cancer
Journal
Nanoscale Advances
Journal Volume
6
Journal Issue
23
Start Page
5949
End Page
5959
ISSN
2516-0230
Date Issued
2024
Author(s)
Tianxun Gong
Zhenjiang Wei
Libin Huang
Yan Hong
Yuan Li
Ke-ling Chen
Wen Huang
Xiaojing Zhong
Jinzhao He
Ming-Yi Lee
En-Chi Chang
Xiaosheng Zhang
Zongguang Zhou
Abstract
Patients benefit greatly from early detection of colorectal cancer, but present diagnostic procedures have high costs, low sensitivity, and low specificity. However, it is still difficult to develop a strategy that can effectively detect cancer early using high-throughput blood analysis. Fano resonance-boosted SERS platform label-free serum creates an effective diagnostic system at the point of care. We obtained 220 high-quality SERS serum spectral datasets from 88 healthy volunteers and 132 patients with colorectal cancer. The biomarker detected in serum was further evaluated using 100 colorectal cancer tissues and adjacent normal intestinal tissues collected from West China Biobanks, West China Hospital, Sichuan University. The results showed that in 97 out of 100 paired samples, the biomarkers were successfully detected using the SERS platform. This demonstrates that Fano resonance-based SERS is highly effective for diagnosing colorectal cancer.
SDGs
Publisher
Royal Society of Chemistry (RSC)
Type
journal article