Clinical characteristics and outcomes of patients with pleural infections due to Stenotrophomonas maltophilia at a medical center in Taiwan, 2004-2012
Journal
European Journal of Clinical Microbiology and Infectious Diseases
Journal Volume
33
Journal Issue
7
Pages
1143-1148
Date Issued
2014
Abstract
Stenotrophomonas maltophilia can cause various clinical diseases; however, pleural infections due to S. maltophilia are rare. We evaluated the clinical characteristics and outcomes of patients with pleural infections (complicated parapneumonic effusion or empyema) due to S. maltophilia who were treated at a medical center in Taiwan from 2004 to 2012. During the study period, 40 patients were treated for pleural infections due to S. maltophilia. The incidence of S. maltophilia pleural infections ranged from 2.66 per 1,000,000 patient-days in 2009 to 12.44 per 1,000,000 patient-days in 2011. Most of the patients with S. maltophilia pleural infections were immunocompromised male adults and all of the infections were acquired in healthcare settings. The majority of patients had polymicrobial pleural infections (n=31, 77.5 %) and the most common pathogen was Pseudomonas aeruginosa (n=12). The causes of pleural infections due to S. maltophilia were pneumonia due to S. maltophilia in two patients (5 %), post-surgical/tube thoracostomy in 26 (65 %) patients, and fistula (bronchopleural, esophagopleural and biliopleural) in 12 (30 %) patients. The 14-day and 30-day mortality rates were 32.5 % and 42.5 %, respectively. Pleural infections due to S. maltophilia are most commonly the result of surgical procedures, thoracostomy, and underlying fistulas. These infections are associated with a high mortality rate, especially among immunocompromised patients. ? 2014 Springer-Verlag.
SDGs
Other Subjects
ceftazidime; ciprofloxacin; cotrimoxazole; imipenem; levofloxacin; meropenem; timentin; acute respiratory failure; adult; aged; antibiotic sensitivity; antibiotic therapy; article; artificial ventilation; bacterial pneumonia; biliary tract disease; biliopleural fistula; bronchopleural fistula; clinical feature; complicated parapneumonic effusion; controlled study; esophagopleural fistula; esophagus disease; female; Gram negative infection; human; immunocompromised patient; incidence; major clinical study; male; middle aged; monotherapy; mortality; outcome assessment; pleura effusion; pleura empyema; pleurisy; postoperative complication; postoperative infection; priority journal; Pseudomonas aeruginosa; respiratory tract fistula; septic shock; sex ratio; Stenotrophomonas maltophilia; stenotrophomonas maltophilia pleural infection; Taiwan; thorax drainage; adolescent; child; Coinfection; cross infection; Empyema, Pleural; epidemiology; Gram-Negative Bacterial Infections; isolation and purification; microbiology; pathology; Pleural Effusion; preschool child; Stenotrophomonas maltophilia; Surgical Wound Infection; treatment outcome; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Coinfection; Cross Infection; Empyema, Pleural; Female; Gram-Negative Bacterial Infections; Humans; Immunocompromised Host; Incidence; Male; Middle Aged; Pleural Effusion; Stenotrophomonas maltophilia; Surgical Wound Infection; Taiwan; Treatment Outcome; Young Adult
Type
journal article