Blood beta-amyloid and tau in down syndrome: A comparison with Alzheimer's disease
Journal
Frontiers in Aging Neuroscience
Journal Volume
8
Journal Issue
JAN
Pages
316
Date Issued
2017
Author(s)
Chieh J.-J.
Huang P.-T.
Chang L.-M.
Huang A.-C.
Chiu M.-J.
Abstract
: The Aβ-40 and Aβ-42 levels and the Aβ-42/Aβ-40 ratio are considered possible biomarkers for the early detection of degeneration in DS. The elevated Aβ-40 and tau levels in DS may indicate early neurodegeneration. The increased Aβ-42 in DS_D may reflect the neurotoxicity of Aβ-42. The paradox of the tau decreases in DS_D could be explained by a burnout phenomenon during long-term neurodegeneration. The different patterns of the plasma beta amyloids and tau protein may imply a different pathogenesis between DS with degeneration and AD in the general population, in spite of their common key pathological features.
SDGs
Publisher
Frontiers Media S.A.
Type
journal article