Sequence composition analysis on arsenic-binding proteins in human cells
Journal
2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops
Date Issued
2010
Author(s)
Abstract
Arsenic is shown to participate in many of transduction pathways in cancer cells [1, 2]. However, up to now, the mechanism of protein-arsenic interactions is still remaining unknown. This study aims at investigating whether the sequence composition of arsenic-binding proteins is distinct to that of background distribution. We first collected two sets of potential arsenic-binding proteins in human lung cancer cells [3] and breast cancer [4], respectively, based on recent studies. These two sets of proteins (TABLE I) were identified previously according to different chemical methods and affinity chromatography coupled to mass spectrometry. Eight proteins that are both present in these two lists were deleted from the breast set of binding proteins to avoid redundancy.
SDGs
Type
conference paper