肺癌醣化酵素基因異常調控之研究(2/3)
Date Issued
2004
Date
2004
Author(s)
余忠仁
DOI
922314B002207
Abstract
Mucins and mucin associated antigens are believed to play an important role in both
invasion and metastasis of cancer cells. The altered expression of mucin peptides in cancer cells,
as well as glycosylation, facilitates tumor cell invasion into blood stream, attachment to
endothelial cells and escape from host immuno-surveillance. Our previous studies had
demonstrated the prognostic implication of mucin expression for lung cancer. Lung cancers
overexpressing sialomucins tend to have higher chance of recurrence and metastasis. The
expression of sialomucin is correlated with the overexpression of an oncoprotein, erbB-2/neu, and
at least one mucin gene (MUC5AC apomucin). We are than interested about the altered
expression of glycosyltransferase genes in lung cancer. Preliminarily, using multiplex PCR to
evaluate the expression of sialyltransferase(ST) and fucosyltransferase (FucT) gene families in
lung cancer (in >50% of patients), we have demonstrated that overexpression of STs and FucTs
are common in lung cancer tissues and cell lines. Daughter cell line (CL1-5) with high
invasiveness and metastasis ability expressed more STs and FucTs than parent cell line (CL1-0
and CL1-1). Clinically, patients bearing tumors with overexpression of ST3GalIII and FucTIII 、
IV 、VI 、VII are liable to cancer recurrence and death. We thus propose a three-year study to
comprehensively study the role of glycosyltransferase genes expression in lung cancer. Is
up-regulation or down-regulation of certain glycosyl -transferase which leads to expression of
cancer-associated sialylated antigens occurs preferentially in lung cancer? Can the altered
expression of glycosyltransferase genes serve as a prognostic marker? Specific
glycosyltransferase genes considered to be important in lung cancers will be cloned and subjected
to further study.
Subjects
Lung cancer
glycosyltransferase
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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