A fluorescence sensor for detection of geranyl pyrophosphate by the chemo-ensemble method
Resource
Journal of Organic Chemistry 74 (2): 895-898
Journal
Journal of Organic Chemistry
Journal Volume
74
Journal Issue
2
Pages
895-898
Date Issued
2009
Author(s)
Abstract
Hexaamide receptor 4 and coumarin phosphate 5 form an ensemble for effective sensing of geranyl pyrophosphate (GPP). Fluorescence resonance energy transfer in the 4 + 5 ensemble diminishes when 5 is replaced by GPP. Receptor 4 binds selectively with GPP over other anions, including fatty acids. The 4-GPP complex in 1:1 stoichiometry is inferred by NMR and fluorescence titrations. Receptor 4 contains a pseudotetrahedral cleft to accommodate GPP via multiple hydrogen bonds, and the two aliphatic chains exert additional hydrophobic interactions.
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journal article
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