Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan
Journal
Anticancer Research
Journal Volume
30
Journal Issue
9
Pages
3649-3653
Date Issued
2010
Author(s)
Wang C.-H.
Wu K.-H.
Peng C.-T.
Wang R.-F.
Tsai C.-W.
Tsai R.-Y.
Linn D.-T.
Tsai F.-J.
Bau D.-T.
Abstract
Aim: The relationship between COX-2 gene and childhood leukemia risk is ambiguous. In this study, the association of genotypic polymorphisms in cyclooxygenase 2 (Cox-2) with childhood leukemia were investigated. Materials and Methods: A total of 266 patients with childhood leukemia and 266 healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped by PCR-RFLP method. Six polymorphic variants of Cox-2 were investigated, including G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, and the associations of specific genotypes with susceptibility to childhood leukemia were analysed. Results: The data showed that although there was no difference in the distribution for each genotype of Cox-2 G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, between the childhood leukemia and control groups (p>0.05), the analysis of combined effect for COX-2 G-765C and intron 6 showed that individuals with GC at G-765C and GG or AG+AA at intron 6 present a slightly higher potential for developing childhood leukemia than other groups. Conclusion: These findings suggest that the C allele of COX-2 G-765C may be responsible for childhood leukemia and may be useful in early detection of child leukemia.
Subjects
Childhood leukemia; Cox-2; Polymorphism
SDGs
Other Subjects
cyclooxygenase 2; cyclooxygenase 2; acute lymphoblastic leukemia; article; child; childhood leukemia; controlled study; female; genetic association; genotype; human; intron; major clinical study; male; preschool child; priority journal; school child; single nucleotide polymorphism; Taiwan; acute lymphoblastic leukemia; genetic predisposition; genetics; polymerase chain reaction; restriction fragment length polymorphism; single nucleotide polymorphism; Child; Cyclooxygenase 2; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Taiwan
Publisher
International Institute of Anticancer Research
Type
journal article