Immunoglobulin A vasculitis: The clinical features and pathophysiology.
Journal
The Kaohsiung journal of medical sciences
Journal Volume
40
Journal Issue
7
Start Page
612
End Page
620
ISSN
2410-8650
Date Issued
2024-07
Author(s)
Abstract
Palpable purpura, gastrointestinal symptoms, joint involvement, and renal disease characterize immunoglobulin A vasculitis (IgAV). Renal involvement ranging from mild proteinuria to severe nephritic or nephrotic syndrome highlights the importance of monitoring kidney function in patients with IgAV. Recognizing these key features is crucial for early diagnosis and appropriate management to prevent long-term complications related to kidney disease. However, the pathogenesis of IgAV remains unclear. Disease mechanisms involve various factors, including the interplay of aberrantly glycosylated IgA, anti-endothelial cell antibodies, and neutrophils following infection triggers, which are the main pathogenic mechanisms of IgAV. Insights from cases of IgAV related to Coronavirus disease 2019 have offered additional understanding of the connection between infection and IgAV pathogenesis. This review provides a valuable resource for healthcare professionals and rheumatology researchers seeking a better understanding of the clinical features and pathophysiology of IgAV.
Subjects
COVID‐19
aberrant‐glycosylated IgA
anti‐endothelial cell antibody
immunoglobulin A vasculitis
pathophysiology
SDGs
Type
review article