Molecular Recognition of Guanine by Ethynyl­-Linked Aniline-Naphthyridine Conjugated Molecules

Abstract
In this thesis we develop the hydrogen-bonding receptors based on the
ethynyl-linked aniline−naphthyridene molecules（APENA、Ac-APENA and
Me-APENA ） for the biologically important Guanine substrate. We
investigate their photophysical properties, binding affinity and the related
experiments. The receptors Ac-APENA and Me-APENA show good and
selective binding affinity for guanine derivatives. The binding of
Ac-APENA and Me-APENA with Guanine（G-10）causes fluorescence
quench. The calculation indicates the binding affinity is very high, Ka =
64200 and 90800 M-1 for Ac-APENA and Me-APENA, respectively. These
molecules can not bind with A-10, and no fluorescence change was ovserved.
These efficient fluorescent chemosensors are potentially useful in bioorganic
chemical researches.