Melanopsin Expressing Retinal Ganglion Cells Connect to Amacrine Cells By Intra-retinal Axon Collateral
Date Issued
2015
Date
2015
Author(s)
Yeh, Po-Ting
Abstract
Retinal structure and functional circuits have been studied for more than a century. It is well known that the information flow of retinal circuit starts form light reception by rods and cones, to horizontal cells, amacrine cells and bipolar cells, and transduces to brain by retinal ganglion cells. However, recent studies indicated that a group of melanopsin containing retinal ganglion cells, named intrinsically photosensitive retinal ganglion cells (ipRGCs), send feedback signal to specific sub-population of amacrine cells by an unknown mechanism. Recent studies showed that ipRGC contain intra-retinal axon collaterals that stratified in the inner plexiform layer, yet the morphology and functions of these collaterals remain unclear. By randomly genetic labeling of ipRGCs in mice, our study shows two morphologically distinct types of ipRGC intra-retinal axon collaterals. We also found those collaterals connect to dopaminergic amacrine cells. Our finding suggests that ipRGCs send feedback signal to amacrine cells via intra-retinal collaterals, which may modulate retinal functions.
Subjects
intrinsically photosensitive retinal ganglion cell
amacrine cell
axon collateral
retinal circuit
Type
thesis
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