Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic-Guided Chemotherapy
Journal
Chemistry - An Asian Journal
Journal Volume
10
Journal Issue
7
Pages
1457-1462
Date Issued
2015
Author(s)
Zakaria, M.B.
Belik, A.A.
Liu, C.-H.
Hsieh, H.-Y.
Liao, Y.-T.
Malgras, V.
Yamauchi, Y.
Wu, K.C.-W.
Abstract
New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS. ? 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
drug delivery; iron oxide; magnetic-guided chemotherapy; nanoparticles; Prussian blue
SDGs
Other Subjects
Amphibious vehicles; Biocompatibility; Chemotherapy; Drug delivery; Iron; Iron oxides; Magnetic levitation vehicles; Magnetism; Metal nanoparticles; Nanomagnetics; Nanoparticles; Platinum compounds; Synthesis (chemical); Bladder cancer cells; Confocal laser scanning microscopy; Drug delivery system; Guiding properties; Intracellular drug delivery; Iron oxide nanoparticle; Prussian blue; Superparamagnetic behavior; Controlled drug delivery; antineoplastic agent; cisplatin; drug carrier; ferric ferrocyanide; ferric ion; ferric oxide; ferrocyanide; magnetite nanoparticle; bladder; cell survival; chemistry; drug delivery system; drug effects; human; magnetism; pathology; porosity; tumor cell line; Urinary Bladder Neoplasms; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Carriers; Drug Delivery Systems; Ferric Compounds; Ferrocyanides; Humans; Magnetics; Magnetite Nanoparticles; Porosity; Urinary Bladder; Urinary Bladder Neoplasms
Type
journal article