Modeling the effects of flow dispersion in arterial spin labeling
Journal
IEEE Transactions on Biomedical Engineering
Journal Volume
56
Journal Issue
6
Pages
1635-1643
Date Issued
2009
Author(s)
Abstract
Recent experimental results have shown that effects such as dispersion and cardiac pulsation have a significant effect on the arterial spin labeling (ASL) signal. These have not been incorporated into the existing ASL models potentially leading to inaccuracies in flow calculation. In this study, we develop a new model, based on physical principles, to model the transit of the ASL signal from the tagging band to the imaging band using the mass transport equation. We relax the assumption of a uniform plug flow, and account for the dispersion caused by the viscous nature of blood. The model also provides a framework within which other physiological aspects can easily be examined. Here, we examine the effects of flow dispersion on the ASL signal, and hence the quantification of cerebral perfusion. Our results suggest that not accounting for flow dispersion may result in inaccurate values of cerebral perfusion. ? 2009 IEEE.
Subjects
Arterial spin labeling
Arterial spin labeling (ASL)
Cerebral blood flow (CBF)
Cerebral perfusion
Flow calculations
Flow dispersion
Flow dispersions
Mass transport equation
New model
Perfusion
Physical principles
Plug flow
Blood
Hemodynamics
Labels
Magnetic resonance
Magnetic resonance imaging
Physiological models
Spin dynamics
Dispersions
article
brain blood flow
brain perfusion
dispersion
mathematical model
signal transduction
spin labeling
viscosity
Algorithms
Blood Flow Velocity
Cerebral Arteries
Cerebrovascular Circulation
Computer Simulation
Hemorheology
Humans
Magnetic Resonance Imaging
Models, Cardiovascular
Spin Labels
Type
journal article