Synthesis and Research of Termosensitive Magnetic Hollow Latex Particle
Date Issued
2009
Date
2009
Author(s)
Lin, Mei-Ling
Abstract
Abstract We synthesis magnetic hollow latex with the behaviors of thermosensitivity by the method of soapless emulsion polymerization. We tests this magnetic hollow latex in some experiments including TEM, LCST and drug release. First, We synthesis the linear copolymer,poly(methyl methacrylate-methyl acrylic acid)(Poly(MMA-MAA)). Using it as seeds, we add different ratio of NIPAAM(N-isopropylacrylamide)/MAA(methacrylic acid) and amount of crosslinker to synthesis Poly(MMA-MAA) /(NIPAAM-MAA). Then we use ammonium hydroxide to dissolve Poly(MMA-MAA) inside of the particle to get hollow P(NIPAAM-MAA) latex which is thermo-sensitive. We use transmission electron microscopy to observe hollow Poly(NIPAAM-MAA) latex. Second, by using the functional group (-COOH) on hollow latex surface to bond with Fe2+and Fe3+, we put ammonia into the latex, and get magnetic hollow latex. The effects of temperature, amount of Fe3O4, and ratio of NIPAAM/MAA on in-situ reaction were investigated. Third, using magenetic hollow latex as seeds, we add different ratio of NIPAAM/MAA and amount of crosslinker to synthesis Poly(NIPAAM-MAA)/Fe3O4/(NIPAAM-MAA) magnetic hollow latex. The magnetic hollow latex containing thermo-sensitive monomers can be used in drug releasing treatment. We observe drug release of magenic hollow latex in different temperature and buffer solution by UV-vis Spectrophotometer.eyword: N-isopropylacrylamide, acrylic acid, hollow latex, magnetic, drug release
Subjects
N-isopropylacrylamide
acrylic acid
hollow latex
magnetic
drug release
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-98-R96549005-1.pdf
Size
23.53 KB
Format
Adobe PDF
Checksum
(MD5):7206f00c97d4f6ec3b50f48bbd05beb7