Potential role of statins for the management of immune reconstitution syndrome
Journal
Medical Hypotheses
Journal Volume
76
Journal Issue
3
Pages
307-310
Date Issued
2011
Author(s)
Singh N.
Abstract
It has become evident that while a robust inflammatory response plays a critical role in eradicating invading microbes, dysregulated immunity can be detrimental to the host if an optimal balance between the inflammatory and anti-inflammatory reactions is disrupted. Opportunistic infection-associated immune reconstitution syndrome is characterized by an aggressive inflammatory immune response and its management remains challenging and largely unknown. Statins, in addition to their lipid lower effects have anti-inflammatory attributes and there is precedence for the use of these agents as a therapeutic modality for autoimmune inflammatory disorders which have similar underlying pathogenesis as immune reconstitution syndrome. We hypothesize that statins may have a potential role for the management of immune reconstitution syndrome. Our proposal has biologic and translational implications for optimizing outcomes in patients with immune reconstitution syndrome. ? 2010 Elsevier Ltd.
SDGs
Other Subjects
antiinflammatory agent; gamma interferon; hydroxymethylglutaryl coenzyme A reductase inhibitor; interleukin 12; interleukin 1beta; interleukin 2; interleukin 6; thalidomide; tumor necrosis factor alpha; article; autoimmune disease; CD4+ T lymphocyte; genetic transcription; graft versus host reaction; human; immune reconstitution inflammatory syndrome; immunity; nonhuman; treatment outcome; Anti-Inflammatory Agents; Autoimmune Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immune Reconstitution Inflammatory Syndrome; Inflammation; Opportunistic Infections
Type
journal article