Association between nonsteroidal anti-inflammatory drugs and atrial fibrillation among a middle-aged population: a nationwide population-based cohort
Journal
British Journal of Clinical Pharmacology
Journal Volume
84
Journal Issue
6
Pages
1290
Date Issued
2018
Author(s)
Abstract
© 2018 The British Pharmacological Society Aims: It remains inconclusive whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of atrial fibrillation (AF), especially in middle-aged Asian populations. In this study, we evaluated the association between NSAID use and the risk of AF in a nationwide population-based study of middle-aged individuals in Taiwan. Methods: A nested case–control study was conducted using the National Health Insurance Research Database (NHIRD) in Taiwan. We identified the cases with a diagnosis of AF (ICD-9-CM codes: 427.31) and the matched controls from three independent Longitudinal Health Insurance Databases (LHIDs) derived from the NHIRD from data collected from 2001 to 2013. Conditional logistic regression models with covariate adjustment were performed to evaluate the association between NSAID use and the risk of AF. Results: A total of 57 058 participants (28 529 AF cases and 28 529 matched controls) were included. Participants with NSAID use had an elevated risk of AF compared to non-users [adjusted odds ratio (AOR) = 1.18, 95% confidence interval (CI): 1.14–1.23]. When further assessing the effects of different classes of NSAIDs on the risk of AF, the results showed that participants who used non-selective NSAIDs had a significantly elevated risk of AF (AOR = 1.18, 95% CI: 1.13–1.23), as did participants with a combined use of selective and non-selective NSAIDs (AOR = 1.30, 95% CI: 1.21–1.39). Conclusions: NSAID use was associated with an increased risk of AF occurrence among the participants included in our study cohort. Closely monitoring the adverse effects of NSAID treatment on the risk of AF will be important, particularly among individuals at high risk.
Subjects
atrial fibrillation; middle-aged population; nationwide population-based study; nonsteroidal anti-inflammatory drugs
SDGs
Other Subjects
nonsteroid antiinflammatory agent; nonsteroid antiinflammatory agent; adult; aged; Article; atrial fibrillation; cardiovascular risk; case control study; cohort analysis; controlled study; drug utilization; female; human; major clinical study; male; middle aged; population research; priority journal; risk assessment; Taiwan; age; atrial fibrillation; chemically induced; factual database; risk factor; time factor; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Atrial Fibrillation; Case-Control Studies; Databases, Factual; Female; Humans; Male; Middle Aged; Risk Assessment; Risk Factors; Taiwan; Time Factors
Publisher
Wiley
Type
journal article