A [2]Rotaxane-based 1H NMR Spectroscopic Probe for the Simultaneous Determination of Physiologically Important Metal Ions in Solution
Date Issued
2007
Date
2007
Author(s)
Chen, Nai-Chia
DOI
zh-TW
Abstract
我們發現實驗室過去所發展的類冠醚大環分子可以辨識2,2’-bipyridine的衍生物，並以此新型分子辨識系統合成出新型的車輪烷分子。此一車輪烷分子對人體中的多種重要金屬離子皆表現出良好的鍵結能力，由於其對生理重要之金屬離子的錯合與解離的動力行為在1H NMR的實驗中為「慢交換」（slow-exchange）的情形，且不同錯合物之間亦具有可茲分辨的不同訊號。如此一來，在一次1H NMR實驗的光譜中即可同時偵測溶液中Li+, Na+, K+, Mg2+, Ca2+等人體重要金屬離子的存在與否。
Herein, we describe a new rotaxane-based molecular recognition
system incorporating 2,2´-bipyridinium ions and crown ether-like
macrocycles. The 1H NMR spectra of the corresponding “neutral”
[2]rotaxane recorded in the presence of a mixture of the physiologically
important Li+, Na+, Mg2+, and Ca2+ ions feature distinct signals for each
of the complexes, with the chemical shifts of pertinent probe protons
identifying the chemical nature of each metal ion. That is to say, the
identification of these metal ions in solution is possible from the analysis
of a single 1H NMR spectrum of a single molecular sensor.
Subjects
超分子化學
車輪烷
金屬離子感測器
supramolecular chemistry
rotaxane
metal ion sensor
Type
thesis
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