Association of leptin receptor polymorphism with insulin resistance
Journal
European Journal of Endocrinology
Journal Volume
150
Journal Issue
5
Pages
725-729
Date Issued
2004
Author(s)
Abstract
Objective: Although the role of the leptin receptor (LEPR) in obesity is well recognized, its role in insulin sensitivity remains unknown. Design: This was a cross-sectional study to investigate the impact of the Q223R polymorphism of the LEPR gene on insulin sensitivity. Methods: Sixty-seven glucose-tolerant Caucasians were enrolled. The insulin sensitivity index and glucose clearance were measured using a hyperglycemic clamp. Genomic DNA was extracted for genotyping. Results: We identified 20 QQ, 31 QR, and 16 RR subjects. The three genotypic groups were similar in age, gender distribution, body mass index, waist-hip ratio, and blood pressure, but differed in the insulin sensitivity index (P = 0.0180) and in glucose clearance (P = 0.0220). Multivariate analyses showed that the Q223R polymorphism was independently associated with the insulin sensitivity index (P = 0.0317) and glucose clearance (P = 0.0436). A trend of increasing low density lipoprotein cholesterol concentration was also observed (P = 0.0447). Conclusion: We have reported the first association of the Q223R polymorphism of the LEPR gene with insulin resistance. ? 2004 Society of the European Journal of Endocrinology.
SDGs
Other Subjects
genomic DNA; glucose; insulin; leptin receptor; low density lipoprotein cholesterol; adult; age; anthropometry; article; blood pressure; body mass; Caucasian; controlled study; disease association; DNA extraction; female; genetic polymorphism; genotype; glucose tolerance; human; hyperglycemia; insulin resistance; insulin sensitivity; major clinical study; male; multivariate analysis; obesity; prevalence; priority journal; sex difference; Adult; Arginine; Cholesterol, LDL; Female; Genotype; Glucose; Glutamine; Humans; Insulin Resistance; Male; Multivariate Analysis; Polymorphism, Genetic; Receptors, Cell Surface
Type
journal article