Ultrasonic pulse-inversion fundamental imaging with liposome microbubbles at 25-50 MHz
Journal
Proceedings - IEEE Ultrasonics Symposium
Part Of
2005 IEEE Ultrasonics Symposium
Journal Volume
1
Journal Issue
Article number: 1602929
Start Page
621
End Page
624
ISSN
1051-0117
Date Issued
2005-09-18
Author(s)
Abstract
Pulse inversion based fundamental imaging was proposed for the enhancement of contrast detection in a previous study. Performance of the imaging method was tested with a commercial contrast agent (Levovist®) at 1.5-3 MHz. In this study, we applied pulse inversion fundamental imaging at 25-50 MHz with liposome microbubbles that were produced in-house. The pulse inversion technique involves two firings with inverted waveforms. Because the reaction of the bubbles under compression is different from that under rarefaction, the signal in the fundamental band is used to enhance the contrast-to-tissue ratio. Phantom experiments were performed. Liposome microbubbles were made in-house with a recipe developed in our lab. Compared to conventional fundamental imaging, the contrast-to-tissue ratio was enhanced by 7~18 dB when the transmit signal was at 25~50MHz. Compared to the conventional second harmonic imaging, the pulse inversion fundamental imaging provides an additional advantage. That is, the bandwidth of the transmit signal is not limited to accommodate both the fundamental and harmonic bands within the passband of the transducer. With this technique, the microbubbles can be combined with ligands for small animal molecular imaging.
Subjects
Ultrasonic imaging
Pulse inverters
Resonant frequency
Resonance
Testing
Animals
High-resolution imaging
Chemistry
Imaging phantoms
Bandwidth
SDGs
Type
conference paper