Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study
Resource
PLoS One, 11(11),
Journal
PLoS ONE
Pages
e0165411
Date Issued
2016
Date
2016
Author(s)
Hsu, Tai-Yi
Shih, Hong-Mo
Wang, Yu-Chiao
Lin, Leng-Chieh
Chen, Chih-Yu
Kao, Chia-Hung
Chen, Chao-Hsien
Chen, Wei-Kung
Yang, Tse-Yen
Cominelli, Fabio
Abstract
Purpose
This study investigated whether alcoholic intoxication (AI) increases the risk of inflammatory bowel disease (IBD) by using a population-based database in Taiwan.
Methods
This retrospective matched-cohort study included 57 611 inpatients with new-onset AI (AI cohort) and 230 444 randomly selected controls (non-AI cohort). Each patient was monitored for 10 years to individually identify those who were subsequently diagnosed with Crohn disease (CD) and ulcerative colitis (UC) during the follow-up period. Cox proportional hazard regression analysis was conducted to determine the risk of IBD in patients with AI compared with controls without AI.
Results
The incidence rate of IBD during the 10-year follow-up period was 2.69 per 1 000 person-years and 0.49 per 1 000 person-years in the AI and non-AI cohorts, respectively. After adjustment for age, sex, and comorbidity, the AI cohort exhibited a 3.17-fold increased risk of IBD compared with the non-AI cohort (hazard ratio [HR] = 3.17, 95% confidence interval [CI] = 2.19–4.58). Compared with the non-AI cohort, the HRs of CD and UC were 4.40 and 2.33 for the AI cohort, respectively. After stratification for the severity of AI according to the duration of hospital stay, the adjusted HRs exhibited a significant correlation with the severity; the HRs of IBD were 1.76, 6.83, and 19.9 for patients with mild, moderate, and severe AI, respectively (p for the trend < .0001).
Conclusion
The risk of IBD was higher in patients with AI and increased with the length of hospital stay.
SDGs
Type
journal article