鼻咽癌與DNA修補基因之流行病學研究
Date Issued
2001-07-31
Date
2001-07-31
Author(s)
鄭玉娟
DOI
892314B002427
Abstract
Genetic polymorphisms of DNA repair
genes have been reported to determine
susceptibility to several cancers. This study
focused on effects of genetic polymorphisms
of DNA repair genes hOGG1 and XRCC1 on
the development of nasopharyngeal
carcinoma (NPC).
We conducted a case-control study to
investigate the genotypes of 334 patients with
NPC and 283 healthy community controls
matched by sex, age and residence. DNA was
extracted from mononuclear cells obtained
from peripheral blood. The polymerase chain
reaction (PCR)-based restriction fragment
length polymorphism assay was used to
identify the genetic polymorphisms. Each
allele frequency of the hOGG1 Cys 326 ,
XRCC1 His 280 and Gln 399 among different
clans in controls was 0.56-0.62, 0.03-0.14
and 0.26-0.31, respectively. After adjustment
for sex, age, clan, and smoking habits, the
odds ratio of developing NPC for hOGG1
codon 326 genotypes of Ser/Cys and Cys/Cys
compared with Ser/Ser genotype was 1.66
(95%CI: 1.03-2.67); for XRCC1 codon 280
genotypes of Arg/His and His/His compared
with Arg/Arg genotype was 0.66 (95%CI:
0.44-0.98). Among subjects with putative
high risk genotypes of both hOGG1 and
XRCC1, the odds ratio of developing NPC
was 3.2 (95%CI: 1.1-9.4). Furthermore,
subjects with putative high risk genotypes of
all hOGG1, XRCC1 and CYP2E1 had an
additive risk effect on NPC. The odds ratio of
developing NPC was nearly 28-fold (95%CI:
3.81-201.66).
The results suggest the polymorphisms of
the DNA repair genes including hOGG1
codon326 and XRCC1 codon280 were
associated with an increased risk of NPC.
There was a synergistic effect for the genetic
polymorphisms of hOGG1, XRCC1 and
CYP2E1 on the development of NPC; the higher the number of the putative risk
genes, the higher the risk of NPC.
Subjects
nasopharyngeal carcinoma
case-control study
DNA
repair genes
repair genes
SDGs
Publisher
臺北市：國立臺灣大學公共衛生學院流行病學研究所
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
892314B002427.pdf
Size
53.58 KB
Format
Adobe PDF
Checksum
(MD5):7f7fbb13d9011f6665e48526b57de3ba