Chitosan/γ-PGA Composite Scaffolds for Wound Dressing Application
Date Issued
2009
Date
2009
Author(s)
Lin, Yu-Yung
Abstract
Chitosan is a biomaterial that has been studied for years. It is biodegradable, biocompatible and has great antibacterial ability. Chitosan can dissolve in acid environment to become a cationic polyelectrolyte though can easily form polyelectrolyte complexes (PECs) with other anionic polyelectrolytes. Through this manner, the properties of chitosan can be enhanced, so chitosan is widely applied in bone tissue regeneration, drug delivery systems and wound dressings. Poly(γ-glutamic acid) (γ-PGA) is also a natural biodegradable polymer. It is well-known for its highly hydrophilicity, and is usually applied as bioglue. In this research, various types of scaffolds were prepared at different repeating unit ratios of chitosan and γ-PGA. The mechanical property, thermal property, and some biological properties were examined for the chitosan/γ-PGA composite scaffolds. At last, animal test was conducted to evaluate the possibility that our scaffold could be a potential wound dressing material. Results of wound closure observation showed that chitosan/γ-PGA composite scaffolds could accelerate the process of wound healing. From histological results, chitosan could suppress the infiltration of inflammatory cells and accelerate fibroblast proliferation while γ-PGA could enhance epithelial migration. Thus, chitosan/γ-PGA composite scaffolds could be potential wound dressing materials.
Subjects
chitosan
γ-PGA
scaffold
wound dressing
Type
thesis
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