肌無力病人體內T細胞的研究(1/3)
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
DOI
912320B002189
Abstract
To identify T cell receptor (TCR) features which might provide basis and targets for
specific immunotherapy for patients with autoimmune myasthenia gravis (MG)
disease, the usage of TCR genes of freshly isolated peripheral blood lymphocytes
from several MG patients was determined. Our results indicated that there is an
apparent biased usage for certain amino acids in the TCR CDR3 region, we call it
the “MG motifs”, among our MG patients when compared with the CDR3 sequences
obtained from our non-MG persons. Strikingly one of the motif-containing TCR
sequences was found in two MG patients with exactly identical TCR peptide sequence,
meaning it was an in vivo selected, functional TCR in the two patients. Importantly,
we found by searching through published documents that these motifs are also apparently present in TCR CDR3 region of in vitro acetylcholine receptor (AChR)
epitope-reactive T cell lines and hybridomas made from experimental autoimmune
MG (EAMG) mice. We are confident that the biased CDR3 motifs on TCRs are
related to this autoimmune disease and further experiments are planned to determine
if our findings can form a base for specific immunotherapy on MG patients. Another
related finding through this study is that there is an apparent differential usage on an
invariant TCR chain gene in MG patients when compared with non-MG persons. The
meaning of this differential usage in regulating immune response is worth further
pursuing.
Subjects
T cell receptor (TCR) gene usage
Myasthenia gravis (MG) disease
Experimental autoimmune MG (EAMG) mice
Publisher
臺北市：國立臺灣大學生化科學研究所
Type
report
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