Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma
Journal
Medical Oncology
Journal Volume
27
Journal Issue
1
Pages
9��15��
Date Issued
2010
Author(s)
Hsu Y.-C.
Wei P.-F.
Tsai Y.-J.
Tsai M.-F.
Abstract
Objective Epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma are involved in the tumorigenesis and regulation of cell metabolism via Akt signaling. F-18 fluorodeoxyglucose-positron emission tomography ([18F]FDG PET), a functional imaging modality, can be used to measure tumor cell metabolism. Thus, in this study, we hypothesize that there exist correlations between EGFR mutation status and [18F]FDG uptake of advanced lung adenocarcinoma. Methods From May 2004 to April 2008, patients with stage IIIB or IV lung adenocarcinoma who underwent [ 18F]FDG PET and EGFR mutation analysis before receiving any treatment were eligible to participate in this study. The association of EGFR mutation status with patient characteristics and the SUVMAX from the [ 18F]FDG PET was evaluated. Multivariate logistic regression analysis was used to analyze predictors of EGFR mutations. Results Seventy-seven lung adenocarcinoma patients were included in this study. EGFR mutations were identified in 49 (64%) of the patients. The [18F]FDG uptake was significantly higher in EGFR-mutant (mean SUVMAX = 10.5 ± 4.7) than wild-type (8.0 ± 3.3) lung adenocarcinoma patients (P = 0.008). The median SUVMAX was 9.5, and patients with an SUVMAX 9.5 were more likely to harbor EGFR mutations (P = 0.009). In the multivariate analysis, an SUVMAX 9.5 remained a statistically significant predictor of EGFR mutations (P = 0.005). Conclusions Among Asian patients with advanced lung adenocarcinoma, those with higher SUVMAX on the [ 18F]FDG PET are more likely to carry EGFR mutations. ? 2008 Humana Press Inc.
SDGs
Other Subjects
epidermal growth factor receptor; fluorodeoxyglucose f 18; adult; aged; article; cancer staging; controlled study; correlation analysis; female; human; lung adenocarcinoma; major clinical study; male; multivariate logistic regression analysis; mutation; positron emission tomography; priority journal; statistical significance; wild type; Adenocarcinoma; Adult; Aged; Aged, 80 and over; DNA, Neoplasm; Female; Fluorodeoxyglucose F18; Genetic Testing; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Receptor, Epidermal Growth Factor
Type
journal article