Infectious complications after heart transplantation in Chinese recipients
Journal
American Journal of Transplantation
Journal Volume
5
Journal Issue
8
Pages
2011-2016
Date Issued
2005
Author(s)
Abstract
Several factors appear to influence the incidence and type of infectious complications among different populations of transplant recipients. This study sought to assess the incidence and type of infection after transplantation in Chinese heart allograft recipients. A total of 130 infectious episodes occurred in 192 consecutive heart transplantation patients between June 1993 and May 2004. The median length of follow-up was 46.7 ± 38.4 months. The 1-, 5- and 10-year survival rates were 81.8 ± 2.8%, 63.0 ± 3.8% and 45.7 ± 7.7%. Infection was the leading cause of early and late deaths. Of the infectious episodes, 66 (51%) were caused by bacteria, 35 (27%) by viruses, 10 (8%) by fungi, 7 (5%) by Mycobacterium tuberculosis and 12 (9%) by other pathogens. The most common bacterial infectious episodes were caused by methicillin-resistant Staphylococcus aureus (20 of 66). The most common viral infections were varicella zoster virus infection in 12 (34%), cytomegalovirus infection in 9 (26%) and hepatitis B virus infection in 8 (23%). There was only one episode of clinical syndrome compatible to Pneumocystis jiroveci pneumonia. In conclusion, there was low incidence of Pneumocystis jiroveci pneumonia and cytomegalovirus infection, and high incidence of Mycobacterium tuberculosis infection in Chinese heart allograft recipients. Copyright ? Blackwell Munksgaard 2005.
SDGs
Other Subjects
antibiotic agent; antivirus agent; azathioprine; cotrimoxazole; cyclosporin; Cytomegalovirus antibody; ganciclovir; immunosuppressive agent; mycophenolic acid 2 morpholinoethyl ester; prednisolone; prednisone; steroid; tacrolimus; thymocyte antibody; adolescent; adult; aged; allograft; article; child; Chinese; cytomegalovirus infection; ethnic group; female; graft rejection; heart transplantation; hepatitis B; human; immunosuppressive treatment; incidence; infant; infection; infectious complication; major clinical study; male; methicillin resistant Staphylococcus aureus; Mycobacterium tuberculosis; organ transplantation; Pneumocystis pneumonia; priority journal; treatment outcome; Varicella zoster virus; Adolescent; Adult; Aged; Bacterial Infections; Child; Child, Preschool; Female; Heart Transplantation; Humans; Incidence; Infant; Infant, Newborn; Male; Middle Aged; Multivariate Analysis; Postoperative Complications; Risk Factors; Survival Rate; Taiwan; Virus Diseases
Type
journal article