Kumada?Corriu Reactions of Alkyl Halides with Alkynyl Nucleophiles
Resource
Organic Letters 6 (9): 1461-1463
Journal
Organic Letters
Journal Volume
6
Journal Issue
9
Pages
1461-1463
Date Issued
2004
Date
2004
Author(s)
Abstract
[reaction: see text] Pd(2)(dba)(3)-Ph(3)P-catalyzed Kumada-Corriu coupling reactions of unactivated alkyl bromides or iodides with an alkynyl nucleophile furnish C(sp)-C(sp)3 bond formation. Alkynyl nucleophiles can be alkynyllithiums or the corresponding Grignard reagents. The superior performance of Ph(3)P ligand over the trialkylphosphine ligands indicates that this cross-coupling reaction may be a reductive-elimination-controlled process.
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Type
journal article
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