行政院國家科學委員會專題研究計畫成果報告:台灣烏腳病地區養殖魚類砷累積之生態毒物模擬(3/3)
Date Issued
2005
2005-07-31
Date
2005
2005-07-31
Author(s)
DOI
932313B002005
Abstract
This proposal focuses on field investigation and
ecotoxicological modeling arsenic accumulation in
aquacultural fish from blackfoot disease area in
Taiwan. A physiologically based pharmacokinetic and
pharmacodynamic (PBPK/PD) model was developed
for arsenic (As) in tilapia Oreochromis mossambicus.
The PBPK/PD model structure consisted of muscle,
gill, gut wall, alimentary canal, and liver, which were
interconnected by blood circulation. We integrate the
target organ concentrations and dynamic response
describing uptake, metabolism, and disposition of As
and the associated area-under-curve (AUC)-based
toxicological dynamics following an acute exposure.
The model validations were compared against the
field observations from real tilapia farms and
previously published uptake/depuration experimental
data, indicating predicted and measured As
concentrations in major organs of tilapia were in
good agreement. The model was utilized to
reasonably simulate and construct a dose-dependent
dynamic response between mortality effect and
equilibrium target organ concentrations. Model
simulations suggest that tilapia gills may serve as a
surrogate sensitive biomarker of short-term exposure
to As. This integrated As PBPK/PD/AUC model
quantitatively estimates target organ concentration
and dynamic response in tilapia and is a strong
framework for future waterborne metal model
development and for refining a biologically based
risk assessment for exposure of aquatic species to
waterborne metals under a variety of scenarios.
Subjects
Arsenic
Area-under-curve
Blackfoot disease
Physiologically based pharmacokinetics
Pharmacodynamics
Tilapia
Publisher
臺北市：國立臺灣大學生物環境系統工程學系暨研究所
Type
report
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