Adiponectin gene polymorphisms and obesity increase the susceptibility to arsenic-related renal cell carcinoma
Journal
Toxicology and Applied Pharmacology
Journal Volume
350
Pages
11-20
Date Issued
2018
Author(s)
Hsueh Y.-M.
Chen W.-J.
Lin Y.-C.
Shiue H.-S.
Yang S.-M.
Ao P.-L.
Su C.-T.
Abstract
Our recent study found that high urinary total arsenic levels were associated with renal cell carcinoma (RCC). Recent studies demonstrated that low circulating adiponectin was related to RCC. The aim of the present study was to explore the relationship between adiponectin gene (ADIPOQ) polymorphisms and RCC and investigate whether individuals with an ADIPOQ risk genotype, obesity, and high urinary total arsenic levels have a modified odds ratio (OR) of RCC. A total of 389 RCC patients and 389 age- and sex-matched controls were recruited between November 2006 and December 2012 in Taiwan. Image-guided biopsy or surgical resection of renal tumors was performed to pathologically verify RCC. Genomic DNA was used to examine the genotypes of the ADIPOQ rs182052, ADIPOQ rs2241766, ADIPOQ rs1501299, and ADIPOQ rs1063539 SNPs by PCR-RFLP. HPLC-HG-AAS was used to measure the concentrations of urinary arsenic species. Participants with the ADIPOQ rs182052 G/A+A/A genotype had a significantly higher OR of RCC compared with those with the ADIPOQ rs182052 G/G genotype. The OR (95% confidence interval [CI]) was 1.70 (1.23–2.36). The OR of RCC for the combined effect of high urinary total arsenic levels and obesity, which was dose-dependent, in individuals with the ADIPOQ rs182052 G/A+A/A genotype was 9.33 (3.85–22.62). The present study found significant combined effects of obesity and the ADIPOQ rs182052 G/A+A/A genotype on the arsenic-related risk of RCC in a population with low arsenic exposure. Arsenic exposure, obesity, and the ADIPOQ rs182052 polymorphism could be predictors of a higher OR of RCC. ? 2018
SDGs
Other Subjects
adiponectin; arsenic; genomic DNA; adiponectin; ADIPOQ protein, human; arsenic; tumor marker; adult; Article; cancer diagnosis; cancer risk; cancer surgery; cancer susceptibility; controlled study; DNA polymorphism; female; genotype; high performance liquid chromatography; histopathology; human; image guided biopsy; major clinical study; male; middle aged; obesity; renal cell carcinoma; restriction fragment length polymorphism; risk; single nucleotide polymorphism; Taiwan; urine level; case control study; genetic predisposition; genetics; kidney tumor; obesity; renal cell carcinoma; urine; Adiponectin; Arsenic; Biomarkers, Tumor; Carcinoma, Renal Cell; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Kidney Neoplasms; Male; Middle Aged; Obesity; Polymorphism, Single Nucleotide; Taiwan
Publisher
Academic Press Inc.
Type
journal article