The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese
Journal
Neurology
Journal Volume
56
Journal Issue
3
Pages
375
Date Issued
2001-02-13
Author(s)
Abstract
Objective: Reports suggest that catechol-O-methyltransferase (COMTL/L) (Val158/Met) and monoamine oxidase B (MAOB) intron 13 genotype polymorphism is associated with PD. To understand the ethnicity-specific effects of genetic polymorphism, we performed a case-control study of the association between PD susceptibility and polymorphism of MAOB and COMT, both separately and in combination, in Taiwanese. Methods: Two hundred twenty-four patients with PD and 197 controls, matched for age, sex, and birthplace, were recruited. MAOB and COMT polymorphism genotyping was performed by using PCR-based restriction fragment length polymorphism (RFLP) analyses. X2, OR, and Fisher's exact tests were used to compare differences in allelic frequencies and genotypes. Results: The MAOB G genotype (G in men and G/G in women) was associated with a 2.07-fold increased relative risk of PD. COMT polymorphism, considered alone, showed no correlation with PD risk; however, a significant synergistic enhancement was found in PD patients harboring both the COMTL and MAOB G genotypes. Conclusions: These results suggest that, in Taiwanese, PD risk is associated with MAOB G intron 13 polymorphism, and this association is augmented in the presence of the COMTL genotype, indicating an interaction of these two dopamine-metabolizing enzymes in the pathogenesis of sporadic PD. However, the relatively low frequencies of these combined genotypes in our study necessitates confirmation with a larger sample size.
SDGs
Other Subjects
amine oxidase (flavin containing) isoenzyme B; catechol methyltransferase; dopamine; methionine; valine; adult; aged; article; case control study; controlled study; dopamine metabolism; ethnic difference; female; gene frequency; genetic analysis; genetic polymorphism; genetic susceptibility; genotype; human; intron; major clinical study; male; Parkinson disease; pathogenesis; polymerase chain reaction; priority journal; restriction fragment length polymorphism; risk assessment; Taiwan
Type
journal article