DBCAT: Database of CpG islands and analytical tools for identifying comprehensive methylation profiles in cancer cells
Journal
Journal of Computational Biology
Journal Volume
18
Journal Issue
8
Pages
1013-1017
Date Issued
2011
Author(s)
Kuo, H.-C.
Lin, P.-Y.
Chung, T.-C.
Chao, C.-M.
Tsai, M.-H.
Abstract
DBCAT (database of CpG islands and analytical tools, http://dbcat.cgm.ntu. edu.tw/), developed to characterize comprehensive DNA methylation profiles in human cancers, is a web-based application and methylation database containing several convenient tools for investigating epigenetic regulation in human diseases. To our knowledge, DBCAT is the first online methylation analytical tool, and is composed of three parts: a CpG island finder, a genome query browser, and a tool for analyzing methylation microarray data. The analytical tools can quickly identify genes with methylated regions from microarray data, compare the methylation status changes between different arrays, and provide functional analysis in addition to colocalizing transcription factor binding sites. ? Copyright 2011, Mary Ann Liebert, Inc.
Other Subjects
transcription factor; article; binding site; computer program; CpG island; DNA methylation; epigenetics; gene expression profiling; gene expression regulation; genetic database; genetics; human; human genome; metabolism; methodology; neoplasm; promoter region; protein binding; Binding Sites; CpG Islands; Databases, Genetic; DNA Methylation; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Neoplasms; Promoter Regions, Genetic; Protein Binding; Software; Transcription Factors
Type
journal article