Unique Microrna Signature and Clinical Outcome of Cancers
Resource
DNA AND CELL BIOLOGY v.26 n.5 pp.283-292
Journal
DNA AND CELL BIOLOGY
Journal Volume
v.26
Journal Issue
n.5
Pages
283-292
Date Issued
2007
Date
2007
Author(s)
YU, SUNG-LIANG
CHEN, HSUAN-YU
YANG, PAN -CHYR
CHEN, JEREMY J. W.
Abstract
MicroRNAs (miRNAs) are endogenous small non-protein-coding RNAs (18-25 nucleotides) that conduct the post- transcriptional repression of hundreds of their target proteins. They regulate many kinds of basic cellular processes including proliferation, differentiation, stress response, and cell death. Recent evidence has shown that deregulation of miRNAs correlates with certain features of diverse cancers ( such as tumorigenesis, differentiation status, and outcome of tumor patients), and indicates that miRNAs can act as oncogenes or tumor suppressors. Here, we summarize these recent studies and provide a new perspective on understanding the role of miRNAs in initiation and progression of cancers. We also discuss the future applications of miRNAs in diagnostic and prognostic implications of cancers.
Subjects
ANGIOTENSIN-II TYPE-1
CELL LUNG-CANCER
CHRONIC LYMPHOCYTIC-LEUKEMIA
DOWN-REGULATION
BREAST-CANCER
C-MYC
SDGs