Amiodarone inhibits apamin-sensitive potassium currents
Journal
PloS one
Journal Volume
8
Journal Issue
7
Pages
e70450
Date Issued
2013-07-29
Author(s)
Turker, Isik
Chang, Po-Cheng
Chen, Zhenhui
Sohma, Yoshiro
Lin, Shien-Fong
Chen, Peng-Sheng
Ai, Tomohiko
Abstract
Apamin sensitive potassium current (I KAS), carried by the type 2 small conductance Ca(2+)-activated potassium (SK2) channels, plays an important role in post-shock action potential duration (APD) shortening and recurrent spontaneous ventricular fibrillation (VF) in failing ventricles.
Subjects
CA2+-ACTIVATED K+ CHANNELS; SMALL-CONDUCTANCE; VENTRICULAR-FIBRILLATION; ATRIAL-FIBRILLATION; ELECTRICAL STORM; CA2+ OVERLOAD; HEART-FAILURE; HEK-293 CELLS; CALCIUM; SK2
Publisher
PUBLIC LIBRARY SCIENCE
Type
journal article