Overall survival and objective response in advanced unresectable hepatocellular carcinoma: A subanalysis of the REFLECT study
Journal
Journal of hepatology
Journal Volume
78
Journal Issue
1
Date Issued
2023-01
Author(s)
Kudo, Masatoshi
Finn, Richard S
Qin, Shukui
Han, Kwang-Hyub
Ikeda, Kenji
Vogel, Arndt
Tovoli, Francesco
Ueshima, Kazuomi
Aikata, Hiroshi
López, Carlos López
Pracht, Marc
Meng, Zhiqiang
Daniele, Bruno
Park, Joong-Won
Palmer, Daniel
Tamai, Toshiyuki
Saito, Kenichi
Dutcus, Corina E
Lencioni, Riccardo
Abstract
Validated surrogate endpoints for overall survival (OS) are important for expediting the clinical study and drug-development processes. Herein, we aimed to validate objective response as an independent predictor of OS in individuals with unresectable hepatocellular carcinoma (HCC) receiving systemic anti-angiogenic therapy.
Subjects
landmark analysis; lenvatinib; mRECIST; response status; surrogate endpoint
SDGs
Type
journal article