Correlation of MR Lumbar Spine Bone Marrow Perfusion with Bone Mineral Density in Female Subjects
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
Shih, Ting-Fang Tiffany
DOI
922314B002172
Abstract
PURPOSE: To prospectively assess lumbar spine bone marrow perfusion at dynamic
magnetic resonance (MR) imaging and correlate perfusion with bone mineral
density (BMD) in female subjects.
MATERIALS AND METHODS: BMD measurement and dynamic MR imaging of
the lumbar spine were performed in 69 female subjects (mean age standard
deviation, 57 years 11). Subjects were stratified into premenopausal (n 19) and
postmenopausal (n 50) groups, with the latter group including both women who
were (n 13) and women who were not (n 37) receiving hormone replacement
therapy. BMD (in grams per square centimeter) was measured with dual energy
absorptiometry in the lumbar spine. Peak enhancement ratio, measured with time–
signal intensity curves calculated from dynamic MR image data, represented bone
marrow perfusion. Peak enhancement ratio was compared with age and BMD by
using linear regression analysis and Pearson correlation.
RESULTS: A significant positive correlation was found for BMD with peak enhancement
ratio of lumbar vertebrae among all subjects (n 69, r 0.63, P .001), all
postmenopausal women (n 50, r 0.50, P .001), and postmenopausal women
without hormone replacement therapy (n 37, r 0.61, P .001). However, the
correlation between BMD and peak enhancement ratio was not significant (P .05)
in premenopausal women (n 19) or postmenopausal women receiving hormone
therapy (n 13). Both BMD and peak enhancement ratio were inversely correlated
with age (P .001, Pearson correlation). Pearson partial correlation coefficient for
peak enhancement ratio and mean in all subjects, with control for inverse correlation
with age, was significant (r 0.63, P .001).
CONCLUSION: Significant correlation was found between the peak enhancement
ratio of vertebral bone marrow and BMD in postmenopausal female subjects. This
result may suggest a vascular component in the pathogenesis of osteoporosis.
Publisher
臺北市：國立臺灣大學醫學院放射線科
Type
journal article
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