Expression of placenta growth factor: An independent factor for prediction of progression and prognosis of oral cancer
Journal
Head and Neck
Journal Volume
32
Journal Issue
10
Pages
1363-1369
Date Issued
2010
Author(s)
Chou C.-H.
Ling Chiang M.
Abstract
Background. Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers. Methods. This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC). Results. We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p =.014) or with more advanced clinical stages (p =.016). Positive lymph node metastasis (p =.008) and PlGF labeling index >40% (p =.010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ?40% (log-rank test, p =.003). Conclusions. The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan. ? 2010 Wiley Periodicals, Inc.
Other Subjects
placental growth factor; adult; article; cancer growth; controlled study; epithelium dysplasia; female; human; human cell; immunohistochemistry; labeling index; lymph node metastasis; major clinical study; male; mouth cancer; multivariate analysis; priority journal; prognosis; proportional hazards model; protein expression; squamous cell carcinoma; Taiwan; tongue cancer; Adult; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Disease Progression; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Multivariate Analysis; Pregnancy Proteins; Prognosis
Type
journal article