Effects of local anesthetics and contrast agents on musculoskeletal regenerative medicine procedures
Journal
Regenerative medicine
Journal Volume
17
Journal Issue
11
Date Issued
2022-11
Author(s)
Zhang, Allan
Wang, Daniel
Diwan, Sudhir
Calodney, Aaron
Rosenthal, Richard
Chang Chien, George C
Abstract
In regenerative medicine, cells, tissues and organs are often replaced, engineered or regrown in order to restore their function after they have been damaged or lost. Local anesthetics, corticosteroids and contrast agents are commonly employed for both diagnostic and therapeutic objectives in interventional pain and musculoskeletal treatments for regenerative medicine. There is growing evidence that routine injectables promote catabolism and disease processes. Thus, understanding the effects of these compounds on regenerative medicine injectates and target tissues such as tenocytes, chondrocytes, nucleus pulposus and ligamentous tissue is critical. This review includes the current research on the effects of local anesthetics and contrast agents, as well as their use and recommendations in regenerative medicine operations.
Subjects
anesthetic; cartilage; contrast agent; lidocaine; ligament; musculoskeletal; nucleus pulposus; regenerative procedure; safety; tendon
SDGs
Type
review