Herpes zoster is associated with prior statin use: A population-based case-control study
Journal
PLoS ONE
Journal Volume
9
Journal Issue
10
Pages
e111268
Date Issued
2014
Author(s)
Abstract
Results: We found that 13.0% of the sampled subjects had used statins, at 15.5% and 12.1% for cases and controls, respectively (p〈0.001). A conditional logistic regression analysis suggested that the adjusted OR of being a statin user before the index date for cases was 1.28 (95% confidence interval (CI): 1.24?1.32) compared to controls. Subjects aged 18?44 years had the highest adjusted OR for prior statin use among cases compared to controls (OR: 1.69; 95% CI: 1.45 ?1.92). Furthermore, we found that the ORs of being a regular and irregular statin user before the index date for cases were 1.32 (95% CI: 1.27?1.38) and 1.23 (95% CI: 1.181.29), respectively, compared to controls.Conclusions: We concluded that prior statin use was associated with HZ occurrence.Background: This study investigated the association between statin use and herpes zoster (HZ) occurrence in a populationbased case-control study.Methods: Study subjects were retrieved from the Taiwan Longitudinal Health Insurance Database 2000. This study included 47,359 cases with HZ and 142,077 controls. We performed conditional logistic regression analyses to calculate the odds ratio (OR) to present the association between HZ and having previously been prescribed statin. ? 2014 Chung et al.
SDGs
Other Subjects
atorvastatin; fluindostatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; mevinolin; pravastatin; rosuvastatin; simvastatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; adult; Article; case control study; controlled study; data base; drug exposure; drug use; female; herpes zoster; human; logistic regression analysis; major clinical study; male; population research; Taiwan; confidence interval; herpes zoster; middle aged; odds ratio; prevalence; Case-Control Studies; Confidence Intervals; Female; Herpes Zoster; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Odds Ratio; Prevalence
Publisher
Public Library of Science
Type
journal article